Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
N-(3-((4-((3-(trifluoromethyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
CAS: 879127-16-9
Molecular Formula: C21H18F3N5O
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Names and Identifiers
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Physico-chemical Properties
| Molecular Formula | C21H18F3N5O |
| Molar Mass | 413.4 |
| Density | 1.456±0.06 g/cm3(Predicted) |
| Solubility | DMSO |
| Appearance | White solid |
| Color | white |
| pKa | 14.51±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Use | Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. |
| Target | Aurora A |
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Risk and Safety
| WGK Germany | 3 |
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Reference
| Reference Show more | 1. Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. |
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.419 ml | 12.095 ml | 24.19 ml |
| 5 mM | 0.484 ml | 2.419 ml | 4.838 ml |
| 10 mM | 0.242 ml | 1.209 ml | 2.419 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
Last Update：2024-01-02 23:10:35
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide - Reference Information
| Biological activity | Aurora kinase inhibitor III is a potent Aurora A kinase inhibitor with an IC50 of 42 nM. It has 386, 3550, 591, 1980, 2510, 887 and> 10,000 nM for BMX, BTK, IGF-1R, c-Src, TRKB, SYK and EGFR respectively. |
| Target | Value |
| Aurora A (Cell-free assay) | 42 nM |
| BMX (Cell-free assay) | 386 nM |
| IGF-1R (Cell-free assay) | 591 nM |
| SYK (Cell-free assay) | 887 nM |
| c-Src (Cell-free assay) | 1980 nM |
Last Update：2024-04-09 21:11:58
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Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide